1-BENZYL-4-DIMETHYLAMINOPIPERIDINE

Base Information

• Chemical Name: 1-BENZYL-4-DIMETHYLAMINOPIPERIDINE
• CAS No.: 64168-08-7
• Molecular Formula: C14H22 N2
• Molecular Weight: 218.342
• Mol file: 64168-08-7.mol

Synonyms:Piperidine,1-benzyl-4-dimethylamino- (4CI); 4-(Dimethylamino)-1-benzylpiperidine; S34177-0

Chemical Property of 1-BENZYL-4-DIMETHYLAMINOPIPERIDINE

Chemical Property:

• PSA: 6.48000
• LogP: 2.15050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-4-(dimethylamino)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-4-DIMETHYLAMINOPIPERIDINE

There total 11 articles about 1-BENZYL-4-DIMETHYLAMINOPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

dimethyl-piperidin-4-yl-amine (50533-97-6) + 4-nitrophenyl bis(carboethoxy) benzylylide → 1-benzyl-N,N-dimethylpiperidin-4-amine (64168-08-7)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

DOI:10.1016/j.cclet.2021.06.069

Reference yield: 84.0%

(4-dimethylaminopiperidin-1-yl)phenylmethanone (93865-36-2) → 1-benzyl-N,N-dimethylpiperidin-4-amine (64168-08-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1248/bpb.25.1030

Reference yield: 12.0%

1-phenylmethyl-4-piperidone (3612-20-2) + N,N-dimethylammonium chloride (506-59-2) → 1-benzyl-N,N-dimethylpiperidin-4-amine (64168-08-7)

Guidance literature:

1-phenylmethyl-4-piperidone; N,N-dimethylammonium chloride; With hydrogenchloride; ethanol; sodium cyanoborohydride; molecular sieve 3A; at 20 ℃; for 168h; pH=6;

With sodium hydroxide; In water;

upstream raw materials:

formaldehyd

4-amino-1-benzylpiperidine

benzylamine

(4-dimethylaminopiperidin-1-yl)phenylmethanone

Downstream raw materials:

dimethyl-piperidin-4-yl-amine