(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Base Information

Chemical Name:(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester
CAS No.:1400704-12-2
Molecular Formula:C₂₆H₃₀ClN₅O₅S
Molecular Weight:560.074
Hs Code.:

(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Synonyms:(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

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Chemical Property of (S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

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Technology Process of (S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

There total 10 articles about (S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1400704-11-1
(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)prop-2-ynylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

: 1400704-12-2
(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; under 30003 Torr; H-Cube;

Reference yield:

: 89694-46-2
2-chloro-5-methoxyphenylboronic acid

: 1400704-12-2
(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide; chloroamine-T / water; methanol / 0.25 h / 20 °C / flask wrapped with aluminum foil

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere; sealed vessel

2.2: 18 h / 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 30003 Torr / H-Cube

With hydrogen; chloroamine-T; triethylamine; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2401-25-4
1-chloro-2-iodo-4-methoxybenzene

: 1400704-12-2
(S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere; sealed vessel

1.2: 18 h / 20 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 30003 Torr / H-Cube

With hydrogen; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; In methanol; N,N-dimethyl-formamide;