(R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

Base Information

Chemical Name:(R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride
CAS No.:1394805-32-3
Molecular Formula:C₂₂H₂₈N₆O*ClH
Molecular Weight:428.965
Hs Code.:

Synonyms:(R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

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Chemical Property of (R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

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Technology Process of (R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

There total 5 articles about (R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394804-66-0
(R)-5-[4-(3-aminopiperidin-1-yl)-6-propylpyrimidin-2-ylamino]-2-methylbenzonitrile

: 75-36-5
acetyl chloride

: 1394805-32-3
(R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

Guidance literature:: (R)-5-[4-(3-aminopiperidin-1-yl)-6-propylpyrimidin-2-ylamino]-2-methylbenzonitrile; acetyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 18h;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: 1394321-71-1
2-methyl-5-(6-oxo-4-propyl-1,6-dihydropyrimidin-2-ylamino)benzonitrile

: 1394805-32-3
(R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 2 h / 110 °C

2: sodium hydrogencarbonate / ethanol / 130 °C / Molecular sieve

3: triethylamine / dichloromethane / 18 h / 20 °C

With sodium hydrogencarbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane;

Reference yield:

: 1394321-72-2
5-(4-chloro-6-propylpyrimidin-2-ylamino)-2-methylbenzonitrile

: 1394805-32-3
(R)-N-{1-[2-(3-cyano-4-methylphenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 130 °C / Molecular sieve

2: triethylamine / dichloromethane / 18 h / 20 °C

With sodium hydrogencarbonate; triethylamine; In ethanol; dichloromethane;