1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

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Chemical Name:1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea
CAS No.:1268390-71-1
Molecular Formula:C₂₉H₃₀ClN₅O₄
Molecular Weight:548.041
Hs Code.:

Synonyms:1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

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Chemical Property of 1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

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Technology Process of 1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

There total 16 articles about 1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1268390-66-4
1-(t-butyloxycarbonyl)-4-chloromethyl-7-azaindole

: 1268390-70-0
1-(5-chloro-2-methoxyphenyl)-3-(2,3-dihydro-1H-indol-4-yl)urea

: 1268390-71-1
1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1268390-71-1
1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (diphenylphosphin)ferrocene / ISOPROPYLAMIDE / 2 h / 120 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 6 h / Reflux

3.1: trichlorophosphate / Reflux

3.2: pH 9

4.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux

5.1: thionyl chloride / dichloromethane / 20 °C

5.2: pH 9

6.1: triethylamine / dmap / dichloromethane / 6 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With sodium tetrahydroborate; thionyl chloride; water; potassium carbonate; triethylamine; calcium chloride; sodium hydroxide; zinc; trichlorophosphate; dmap; (diphenylphosphin)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 479553-01-0
1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid

: 1268390-71-1
1-(2-methoxy-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-2,3-dihydro-1H-indol-4-yl}urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / Reflux

1.2: pH 9

2.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux

3.1: thionyl chloride / dichloromethane / 20 °C

3.2: pH 9

4.1: triethylamine / dmap / dichloromethane / 6 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; calcium chloride; trichlorophosphate; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;