methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate

Base Information

• Chemical Name: methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate
• CAS No.: 139347-35-6
• Molecular Formula: C₁₆H₂₃N₂O₈P
• Molecular Weight: 402.341
• Mol file: 139347-35-6.mol

Synonyms:methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate

Chemical Property of methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate

There total 3 articles about methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4-nitro-benzoyl chloride (122-04-3) + methyl D,L-2-amino-4-(diethoxyphosphinyl)butanoate hydrochloride (139405-64-4) → methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate (139347-35-6)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jm00087a012

Reference yield:

methyl D,L-2-formamido-4-(diethoxyphosphinyl)butanoate (139347-34-5) → methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate (139347-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl (sat. sol. in MeOH), SOCl₂ / 18 h / Ambient temperature

2: 30 percent / Et₃N / CH₂Cl₂

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00087a012

Reference yield:

methyl D,L-2-amino-4-phosphonobutanoate hydrochloride (139347-33-4) → methyl D,L-2-<(4-nitrobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate (139347-35-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 3 h / Heating

2: HCl (sat. sol. in MeOH), SOCl₂ / 18 h / Ambient temperature

3: 30 percent / Et₃N / CH₂Cl₂

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00087a012

upstream raw materials:

4-nitro-benzoyl chloride

methyl D,L-2-amino-4-(diethoxyphosphinyl)butanoate hydrochloride

methyl D,L-2-formamido-4-(diethoxyphosphinyl)butanoate

methyl D,L-2-amino-4-phosphonobutanoate hydrochloride

Downstream raw materials:

methyl D,L-2-<(4-aminobenzoyl)amino>-4-(diethoxyphosphinyl)butanoate

D.L-2-<(nitrobenzoyl)amino>-4-phosphonobutanoic acid

methyl D,L-2-<(N²-acetyl-5-deazapteroyl)amino>-4-(diethoxyphosphinyl)butanoate

N(α)-(5-deazapteroyl)-DL-2-amino-4-phosphonobutanoic acid