1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

Base Information

Chemical Name:1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea
CAS No.:874796-29-9
Molecular Formula:C₂₄H₃₂N₂O₃Si
Molecular Weight:424.615
Hs Code.:

Synonyms:1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

Suppliers and Price of 1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

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Technology Process of 1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

There total 1 articles about 1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 104-94-9
4-methoxy-aniline

: 224315-54-2
2-(4-((tert-butyldimethylsilyl)oxy)but-1-yn-1-yl)aniline

: 874796-29-9
1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

Guidance literature:: bis(trichloromethyl) carbonate; 2-[4-(tert-butyldimethylsilanyloxy)but-1-ynyl]phenylamine; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

4-methoxy-aniline; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol052562z

Reference yield: 84.0%

: 874796-29-9
1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

: 874796-41-5
N-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-N'-(4-methoxyphenyl)carbodiimide

Guidance literature:: With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol052562z

Reference yield:

: 874796-29-9
1-[2-[(4-tert-butyldimethylsiloxy)-1-butynyl]phenyl]-3-(4-methoxyphenyl)urea

: 3-[(tert-butyldimethylsiloxy)ethyl]-1-(4-methoxyphenyl)pyrrolo[2,3-b]indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / CBr₄; PPh₃; Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

2: 48 percent / Co₂(CO)8; TMTU / benzene / 70 °C

With dicobalt octacarbonyl; carbon tetrabromide; 1,1,3,3-tetramethyl-2-thiourea; triethylamine; triphenylphosphine; In dichloromethane; benzene; 2: aza-Pauson-Khand reaction;
DOI:10.1021/ol052562z