Technology Process of (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylic acid
There total 5 articles about (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol; water;
at 20 ℃;
for 12h;
Schlenk technique;
Inert atmosphere;
Sealed tube;
DOI:10.1039/c6cc09643c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bis(pinacol)diborane; copper(II) acetate monohydrate; sodium acetate; 4,4'-di-tert-butyl-2,2'-bipyridine / 1,2-dichloro-ethane / 16 h / 100 °C / Schlenk technique; Inert atmosphere
2.1: palladium diacetate; tris-(o-tolyl)phosphine / toluene / 24 h / 60 °C / Schlenk technique; Inert atmosphere; Sealed tube
2.2: 100 °C / Schlenk technique; Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 50 °C / Schlenk technique; Inert atmosphere; Sealed tube
4.1: sodium hydroxide / methanol; water / 12 h / 20 °C / Schlenk technique; Inert atmosphere; Sealed tube
With
sodium acetate; palladium diacetate; copper(II) acetate monohydrate; potassium carbonate; tris-(o-tolyl)phosphine; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide;
In
methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c6cc09643c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate; tris-(o-tolyl)phosphine / toluene / 24 h / 60 °C / Schlenk technique; Inert atmosphere; Sealed tube
1.2: 100 °C / Schlenk technique; Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 50 °C / Schlenk technique; Inert atmosphere; Sealed tube
3.1: sodium hydroxide / methanol; water / 12 h / 20 °C / Schlenk technique; Inert atmosphere; Sealed tube
With
palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine; sodium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c6cc09643c
