methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

Base Information

Chemical Name:methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate
CAS No.:882999-65-7
Molecular Formula:C₁₉H₁₃Cl₂F₂NO₃
Molecular Weight:412.22
Hs Code.:

Synonyms:methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

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Technology Process of methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

There total 4 articles about methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 882999-63-5
(E)-3-[1-(2,4-dichlorobenzyl)-2,3-dioxo-2,3-dihydro-1H-indol-7-yl]acrylic acid methyl ester

: 882999-65-7
methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 5 - 20 ℃; for 72h;

Reference yield: 91.0%

: methyl (E)-3-(3,3-difluoro-2-oxoindolin-7-yl)acrylate

: 94-99-5
2,4-Dichlorobenzyl chloride

: 882999-65-7
methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube;
DOI:10.1039/c6cc09643c

Reference yield:

: 615-36-1
2-bromoaniline

: 882999-65-7
methyl (E)-3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindolin-7-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(pinacol)diborane; copper(II) acetate monohydrate; sodium acetate; 4,4'-di-tert-butyl-2,2'-bipyridine / 1,2-dichloro-ethane / 16 h / 100 °C / Schlenk technique; Inert atmosphere

2.1: palladium diacetate; tris-(o-tolyl)phosphine / toluene / 24 h / 60 °C / Schlenk technique; Inert atmosphere; Sealed tube

2.2: 100 °C / Schlenk technique; Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 50 °C / Schlenk technique; Inert atmosphere; Sealed tube

With sodium acetate; palladium diacetate; copper(II) acetate monohydrate; potassium carbonate; tris-(o-tolyl)phosphine; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c6cc09643c