1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

Base Information

Chemical Name:1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea
CAS No.:217654-62-1
Molecular Formula:C₂₂H₂₂ClF₂N₉O₂
Molecular Weight:517.926
Hs Code.:

Synonyms:1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

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Chemical Property of 1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

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Technology Process of 1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

There total 10 articles about 1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 217654-58-5
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

: 217654-62-1
1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

Guidance literature:: With trichlorophosphate; In N,N-dimethyl acetamide; ethyl acetate; at 20 ℃; for 16h;
DOI:10.1248/cpb.48.1947

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 217654-62-1
1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 32 h / 160 °C

2: 92 percent / N₂H₄*H₂O; FeCl₃; C* / methanol / 24 h / Heating

3: 68 percent / NaN₃; AcOH / 4 h / 90 °C

4: H₂; 6N aq. HCl / 10 percent Pd/C / methanol; tetrahydrofuran / 0.42 h / 20 °C

5: pyridine / ethyl acetate; tetrahydrofuran / 1 h / 20 °C

6: 86 percent / Et₃N / ethyl acetate / 1.5 h / Heating

7: 70 percent / POCl₃ / ethyl acetate; N,N-dimethyl-acetamide / 16 h / 20 °C

With pyridine; hydrogenchloride; sodium azide; hydrogen; iron(III) chloride; potassium carbonate; pyrographite; hydrazine hydrate; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1947

Reference yield:

: 65052-89-3
N,N-dibenzyl-4-nitroaniline

: 217654-62-1
1-(2-chloroethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazoyl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / N₂H₄*H₂O; FeCl₃; C* / methanol / 24 h / Heating

2: 68 percent / NaN₃; AcOH / 4 h / 90 °C

3: H₂; 6N aq. HCl / 10 percent Pd/C / methanol; tetrahydrofuran / 0.42 h / 20 °C

4: pyridine / ethyl acetate; tetrahydrofuran / 1 h / 20 °C

5: 86 percent / Et₃N / ethyl acetate / 1.5 h / Heating

6: 70 percent / POCl₃ / ethyl acetate; N,N-dimethyl-acetamide / 16 h / 20 °C

With pyridine; hydrogenchloride; sodium azide; hydrogen; iron(III) chloride; pyrographite; hydrazine hydrate; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1248/cpb.48.1947