1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

Base Information

Chemical Name:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea
CAS No.:217654-58-5
Molecular Formula:C₂₂H₂₃F₂N₉O₃
Molecular Weight:499.48
Hs Code.:

Synonyms:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

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Chemical Property of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

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Technology Process of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

There total 8 articles about 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 217654-45-0
phenyl 4-(1H-1-tetrazolyl)phenylcarbamate

: 217654-56-3
(2R,3R)-2-(2,4-difluorophenyl)-3-(2-hydroxyethyl)amino-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 217654-58-5
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

Guidance literature:: With triethylamine; In ethyl acetate; for 1.5h; Heating;
DOI:10.1248/cpb.48.1947

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 217654-58-5
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 32 h / 160 °C

2: 92 percent / N₂H₄*H₂O; FeCl₃; C* / methanol / 24 h / Heating

3: 68 percent / NaN₃; AcOH / 4 h / 90 °C

4: H₂; 6N aq. HCl / 10 percent Pd/C / methanol; tetrahydrofuran / 0.42 h / 20 °C

5: pyridine / ethyl acetate; tetrahydrofuran / 1 h / 20 °C

6: 86 percent / Et₃N / ethyl acetate / 1.5 h / Heating

With pyridine; hydrogenchloride; sodium azide; hydrogen; iron(III) chloride; potassium carbonate; pyrographite; hydrazine hydrate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1947

Reference yield:

: 65052-89-3
N,N-dibenzyl-4-nitroaniline

: 217654-58-5
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1-(2-hydroxyethyl)-3-[4-(1H-1-tetrazoyl)phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / N₂H₄*H₂O; FeCl₃; C* / methanol / 24 h / Heating

2: 68 percent / NaN₃; AcOH / 4 h / 90 °C

3: H₂; 6N aq. HCl / 10 percent Pd/C / methanol; tetrahydrofuran / 0.42 h / 20 °C

4: pyridine / ethyl acetate; tetrahydrofuran / 1 h / 20 °C

5: 86 percent / Et₃N / ethyl acetate / 1.5 h / Heating

With pyridine; hydrogenchloride; sodium azide; hydrogen; iron(III) chloride; pyrographite; hydrazine hydrate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1248/cpb.48.1947