O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine

Base Information

• Chemical Name: O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine
• CAS No.: 1092408-11-1
• Molecular Formula: C₁₂H₁₅F₃N₂O₄S
• Molecular Weight: 340.323
• Mol file: 1092408-11-1.mol

Synonyms:O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine

Chemical Property of O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine

There total 7 articles about O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione (1092408-10-0) → O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1092408-11-1)

Guidance literature:

With hydrazine; In ethanol; water; for 1h; Product distribution / selectivity;

Reference yield:

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol (1092408-14-4) → O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1092408-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 48 h / 0 - 20 °C

2: hydrazine / ethanol; water / 1 h

With triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

4-piperidone hydrochloride (41979-39-9) → O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1092408-11-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide / 0.5 h / 80 °C

1.2: 0 - 20 °C

2.1: sodium tetrahydroborate / methanol / 0.75 h / 0 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 48 h / 0 - 20 °C

4.1: hydrazine / ethanol; water / 1 h

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione

tert-butyl 4-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)piperidine-1-carboxylate

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-one

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol

Downstream raw materials:

(E)-3-((1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxyimino)methyl)benzonitrile

bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime

N-[1-(4-trifluoromethoxybenzenesulfonyl)piperidin-4-yloxy]oxalamic acid ethyl ester

1-(3-fluorophenyl)-3-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)urea