bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime

Base Information

• Chemical Name: bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime
• CAS No.: 1092408-13-3
• Molecular Formula: C₂₅H₂₁F₅N₂O₄S
• Molecular Weight: 540.511
• Mol file: 1092408-13-3.mol

Synonyms:bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime

Chemical Property of bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime

There total 5 articles about bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1092408-11-1) + 4,4'-Difluorobenzophenone (345-92-6) → bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime (1092408-13-3)

Guidance literature:

With acetic acid; In ethanol; at 100 ℃; for 48h;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime (1092408-13-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 1.5 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 80 °C

3.2: 0.67 h / 0 - 20 °C

4.1: hydrazine / ethanol; water / 1 h

5.1: acetic acid / ethanol / 48 h / 100 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

tert-butyl 4-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)piperidine-1-carboxylate (143539-99-5) → bis(4-fluorophenyl)methanone O-1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxime (1092408-13-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 80 °C

2.2: 0.67 h / 0 - 20 °C

3.1: hydrazine / ethanol; water / 1 h

4.1: acetic acid / ethanol / 48 h / 100 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; hydrazine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine

4,4'-Difluorobenzophenone

tert-butyl 4-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)piperidine-1-carboxylate

1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-one