2-benzyloxy-5-aminoacetophenone

Base Information

• Chemical Name: 2-benzyloxy-5-aminoacetophenone
• CAS No.: 1429022-32-1
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol file: 1429022-32-1.mol

Synonyms:2-benzyloxy-5-aminoacetophenone

Chemical Property of 2-benzyloxy-5-aminoacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-5-aminoacetophenone

There total 5 articles about 2-benzyloxy-5-aminoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2-(benzyloxy)-5-nitrophenyl)ethanone (1429022-31-0) → 2-benzyloxy-5-aminoacetophenone (1429022-32-1)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; at 45 ℃; for 3h;

DOI:10.3390/molecules18033577

Reference yield:

4-nitrophenol acetate (830-03-5) → 2-benzyloxy-5-aminoacetophenone (1429022-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / nitrobenzene / 6 h / 140 °C

2: potassium carbonate; potassium iodide; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile; water / 2 h / Reflux

3: tin(II) chloride dihdyrate / ethanol / 3 h / 45 °C

With aluminum (III) chloride; tin(II) chloride dihdyrate; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; potassium iodide; In ethanol; water; nitrobenzene; acetonitrile;

DOI:10.3390/molecules18033577

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 2-benzyloxy-5-aminoacetophenone (1429022-32-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / 90 - 95 °C

2: aluminum (III) chloride / nitrobenzene / 6 h / 140 °C

3: potassium carbonate; potassium iodide; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile; water / 2 h / Reflux

4: tin(II) chloride dihdyrate / ethanol / 3 h / 45 °C

With aluminum (III) chloride; tin(II) chloride dihdyrate; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; potassium iodide; sodium hydroxide; In ethanol; water; nitrobenzene; acetonitrile;

DOI:10.3390/molecules18033577

upstream raw materials:

4-nitro-phenol

4-nitrophenol acetate

5-nitrosalicylic acid

benzyl chloride

Downstream raw materials:

N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)benzamide

N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-chlorobenzamide

N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-(trifluoromethyl)benzamide

N-(4-(benzyloxy)-3-(2-bromoacetyl)phenyl)-4-methoxybenzamide