N-Methyl-3,5-dichlorobenzylamine

Base Information

• Chemical Name: N-Methyl-3,5-dichlorobenzylamine
• CAS No.: 90390-21-9
• Molecular Formula: C8H9 Cl2 N
• Molecular Weight: 190.07
• DSSTox Substance ID: DTXSID60238140
• Nikkaji Number: J358.958G
• Wikidata: Q83120397
• ChEMBL ID: CHEMBL1182955
• Mol file: 90390-21-9.mol

Synonyms:ME 93;ME 93 hydrochloride;ME-93;N-methyl-3,5-dichlorobenzylamine

Chemical Property of N-Methyl-3,5-dichlorobenzylamine

Chemical Property:

• Boiling Point: 240.6°Cat760mmHg
• Flash Point: 99.3°C
• PSA: 12.03000
• Density: 1.226g/cm³
• LogP: 3.10370
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 189.0112047
• Heavy Atom Count: 11
• Complexity: 109

Purity/Quality:

98%Min ^*data from raw suppliers

[(3,5-dichlorophenyl)methyl](methyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=CC(=CC(=C1)Cl)Cl

Technology Process of N-Methyl-3,5-dichlorobenzylamine

There total 4 articles about N-Methyl-3,5-dichlorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-methyl-amine → N-methyl-3,5-dichlorobenzylamine (90390-21-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

DOI:10.1021/jm00375a005

Reference yield:

3,5-dichlorobenzaldehyde (10203-08-4) → N-methyl-3,5-dichlorobenzylamine (90390-21-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 80 °C

2: LiAlH₄ / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00375a005

Reference yield:

3,5-dichlorobenzaldehyde (10203-08-4) + methylamine (74-89-5) → N-methyl-3,5-dichlorobenzylamine (90390-21-9)

Guidance literature:

3,5-dichlorobenzaldehyde; methylamine; In methanol; at 20 ℃; for 0.5h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b00561

upstream raw materials:

3,5-dichlorobenzaldehyde

methylamine

Refernces

• 1、 -. "TACHYKININ RECEPTOR ANTAGONISTS". Page 29. . Retrieved 2010/02/10.