(R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Base Information

Chemical Name:(R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate
CAS No.:1174549-32-6
Molecular Formula:C₁₉H₂₄O₅
Molecular Weight:332.397
Hs Code.:

Synonyms:(R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Suppliers and Price of (R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

There total 9 articles about (R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 847909-76-6
(5R)-1-(7,7-dibromo-5-methoxyhepta-2,6-dienyloxymethyl)-4-methoxybenzene

: 541-41-3
chloroformic acid ethyl ester

: 1174549-32-6
(R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Guidance literature:: (5R)-1-(7,7-dibromo-5-methoxyhepta-2,6-dienyloxymethyl)-4-methoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

chloroformic acid ethyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/chem.201501304

Reference yield: 89.0%

: 1174549-41-7
C₁₆H₂₀O₃

: 541-41-3
chloroformic acid ethyl ester

: 1174549-32-6
(R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - -45 ℃;
DOI:10.1016/j.tetlet.2009.04.129

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1174549-32-6
(R,Z)-ethyl 4-methoxy-8-((4-methoxyphenyl)methoxy)oct-6-en-2-ynoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.1: quinoline; 5% Pd-CaCO3; hydrogen / hexane / 0.5 h / 20 °C

5.1: water; hydrogenchloride / tetrahydrofuran / 1 h / 20 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

6.2: 1 h / -78 - 20 °C / Inert atmosphere

7.1: triphenylphosphine / dichloromethane / 0.58 h / 0 - 20 °C

8.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

8.2: 1.5 h / -78 °C / Inert atmosphere

With quinoline; hydrogenchloride; n-butyllithium; oxalyl dichloride; 5% Pd-CaCO3; water; hydrogen; sodium hydride; dimethyl sulfoxide; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 6.1: |Swern Oxidation / 6.2: |Swern Oxidation;
DOI:10.1002/chem.201501304