N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine

Base Information

• Chemical Name: N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine
• CAS No.: 57699-55-5
• Molecular Formula: C₁₂H₁₈N₂O₃
• Molecular Weight: 238.287
• Mol file: 57699-55-5.mol

Synonyms:N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine

Chemical Property of N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine

There total 8 articles about N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-(4-Hydroxybenzyliden)-carbazinsaeure-tert-butylester (57699-48-6) → N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine (57699-55-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 0.5h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm960022p

Reference yield: 25.0%

N-t-butoxycarbonyl-N'-4-hydroxybenzaldehyde hydrazone (57699-48-6) → N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine (57699-55-5)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 1.5h;

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → N-t-butoxycarbonyl-N'-4-hydroxybenzyl hydrazine (57699-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / 20 °C

2: 25 percent / ammonium formate / Pd/C / methanol / 1.5 h

With ammonium formate; palladium on activated charcoal; In methanol;

upstream raw materials:

N-t-butoxycarbonyl-N'-4-hydroxybenzaldehyde hydrazone

3-(4-Hydroxybenzyliden)-carbazinsaeure-tert-butylester

t-butoxycarbonylhydrazine

4-hydroxy-benzaldehyde

Downstream raw materials:

cumenyl chloride

N-t-butoxycarbonyl-azatyrosine ethyl ester

N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-hydroxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester

Refernces

• 1、 -. "Antiretroviral hydrazine derivatives". . . Retrieved 2008/06/13.
• 2、 -. "RETROVIRAL PROTEASE INHIBITING COMPOUNDS". . . Retrieved 2008/06/13.