N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide
• CAS No.: 1365543-92-5
• Molecular Formula: C₁₁H₁₁F₃N₂O₂S
• Molecular Weight: 292.282

Synonyms:N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Chemical Property of N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

There total 6 articles about N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365544-25-7) → N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365543-92-5)

Guidance literature:

With iron-doped palladium on carbon; hydrogen; In methanol; water; for 7h; under 1875.19 Torr;

Reference yield:

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene (1365544-29-1) → N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365543-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / water; dichloromethane / 1 h / 20 °C

1.2: 0.83 h / 20 - 25 °C

2.1: iron-doped palladium on carbon; hydrogen / methanol; water / 7 h / 1875.19 Torr

With iron-doped palladium on carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; water;

Reference yield:

para-nitrobenzenethiol (1849-36-1) → N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365543-92-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.5 h / 30 °C

1.2: 8 h / 135 - 140 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C

2.2: 14.25 h / 20 - 25 °C

3.1: potassium carbonate; Oxone / methanol; sulfolane; water / 1 h / 25 °C / pH 10

4.1: acetonitrile / 16 h / 20 °C

5.1: potassium carbonate / water; dichloromethane / 1 h / 20 °C

5.2: 0.83 h / 20 - 25 °C

6.1: iron-doped palladium on carbon; hydrogen / methanol; water / 7 h / 1875.19 Torr

With Oxone; iron-doped palladium on carbon; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; sulfolane; methanol; dichloromethane; water; acetonitrile; mineral oil;

upstream raw materials:

N-[cyclopropyl(4-nitrophenyl)-lambda⁴-sulphanylidene]-2,2,2-trifluoroacetamide

cyclopropyl(imino)(4-nitrophenyl)-λ⁶-sulfanone

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene

N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Downstream raw materials:

N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

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