Diethylpropion

Base Information

• Chemical Name: Diethylpropion
• CAS No.: 90-84-6
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• European Community (EC) Number: 202-019-1
• UNII: Q94YYU22B8
• DSSTox Substance ID: DTXSID6022929
• Nikkaji Number: J4.327C
• Wikipedia: Amfepramone
• Wikidata: Q2356505
• NCI Thesaurus Code: C61721
• RXCUI: 3389
• Pharos Ligand ID: 9DKQLD7D29DN
• Metabolomics Workbench ID: 145666
• ChEMBL ID: CHEMBL1194666
• Mol file: 90-84-6.mol

Synonyms:2-Diethylaminopropiophenone;Amfepramon;Amfepramone;Anorex;Delgamer;Diethylpropion;Diethylpropion Hydrochloride;Dietil retard;Dietil-retard;Dietilretard;Hydrochloride, Diethylpropion;Ifa Norex;Lipomin;Maruate;Modératan;Neobes;Nobesine;Norex, Ifa;Phepranon;Préfamone;Propion;Regenon;Regibon;Tenuate;Tepanil

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Diethylpropion

Chemical Property:

• Refractive Index: 1.5175 (estimate)
• Boiling Point: 292℃
• PKA: 8.49±0.25(Predicted)
• Flash Point: 95℃
• PSA: 20.31000
• Density: 0.972
• LogP: 2.59960
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 205.146664230
• Heavy Atom Count: 15
• Complexity: 193

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Weight Loss Agents
• Canonical SMILES: CCN(CC)C(C)C(=O)C1=CC=CC=C1
• Uses: appetite depressant;stimulating secretion of norepinephrine

Technology Process of Diethylpropion

There total 15 articles about Diethylpropion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

diethylamine (109-89-7) + (+/-)-cathinone (5265-18-9) → amfepramone (90-84-6,39648-49-2,39648-50-5)

Guidance literature:

at 90 ℃; for 1.5h; Temperature;

Reference yield: 85.0%

2-bromo-1-phenyl-1-propanone (2114-00-3) + diethylamine (109-89-7) → amfepramone (90-84-6,39648-49-2,39648-50-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; at 40 ℃; for 16h;

DOI:10.1021/jo049677l

Reference yield: 80.0%

diethylamine (109-89-7) + 1-phenyl-propan-1-one (93-55-0) → amfepramone (90-84-6,39648-49-2,39648-50-5)

Guidance literature:

1-phenyl-propan-1-one; With 1,10-Phenanthroline; copper(ll) bromide; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

diethylamine; With oxygen; In dimethyl sulfoxide; at 35 ℃; for 1.5h; under 760.051 Torr; Sealed tube;

DOI:10.1021/ja4096472

upstream raw materials:

2-bromo-1-phenyl-1-propanone

diethylamine

N,N-diethylphenacylamine

1-phenyl-propan-1-one

Downstream raw materials:

2-Diethylamino-1-phenyl-propan-1-ol

2-Diethylamino-1-phenyl-propan-1-ol

Refernces

• 1、 Wu, Weilong,You, Cai,Yin, Congcong,Liu, Yuanhua,Dong, Xiu-Qin,Zhang, Xumu. "Enantioselective and Diastereoselective Construction of Chiral Amino Alcohols by Iridium-f-Amphox-Catalyzed Asymmetric Hydrogenation via Dynamic Kinetic Resolution". supporting information. p. 2548 - 2551. Retrieved 2017/05/24.
• 2、 Xu, Senhan,Wu, Ping,Zhang, Wei. "1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses of α-bromo/amino ketones from alkenes in water". . p. 11389 - 11395. Retrieved 2016/12/18.