(S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

Base Information

Chemical Name:(S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester
CAS No.:1392840-51-5
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:

Synonyms:(S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

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Chemical Property of (S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

Chemical Property:

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Technology Process of (S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

There total 1 articles about (S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 105-45-3
acetoacetic acid methyl ester

: 922-67-8
propynoic acid methyl ester

: 1392840-51-5
(S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

Guidance literature:: (S)-1-phenyl-ethylamine; acetoacetic acid methyl ester; In methanol; for 2h; Reflux;

propynoic acid methyl ester; In methanol; for 48h; Reflux;

Reference yield:

: 1392840-51-5
(S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

: 1392840-52-6
(S)-5-bromo-2-methyl-6-oxo-1-(1-phenyl-ethyl)-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

Guidance literature:: With N-Bromosuccinimide; sodium methylate; In methanol; for 6h; Reflux;

Reference yield:

: 1392840-51-5
(S)-4-[1-(1-phenyl-ethylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

: 1392843-41-2
(S)-3-{[5-hydroxy-2-oxo-3-phenyl-1-(1-phenyl-ethyl)-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sodium methylate; N-Bromosuccinimide / methanol / 6 h / Reflux

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

4: sodium methylate / methanol / 16 h / 20 °C / Cooling with ice

5: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

6: N-Bromosuccinimide / dichloromethane / 3 h / Reflux

7: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere

8: sodium methylate / methanol / 16 h / Reflux

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;