methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

Base Information

Chemical Name:methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate
CAS No.:1318898-60-0
Molecular Formula:C₄₇H₅₄N₈O₄
Molecular Weight:794.997
Hs Code.:

methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

Synonyms:methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

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Chemical Property of methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

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Technology Process of methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

There total 7 articles about methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.5%

: methyl [(1S)-2-methyl-1-({(2S,4S)-4-methyl-2-[5-(6-{2-[(2S,4S)-4-methyl-2-pyrrolidinyl]-1H-imidazol-4-yl}-2-naphthalenyl)-1H-benzimidazol-2-yl]-1-pyrrolidinyl}carbonyl)propyl]carbamate dihydrochloride

: 29810-09-1
(R)-2-(dimethylamino)-2-phenylacetic acid

: 1318898-60-0
methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1590-25-6
1-(6-bromonaphthalen-2-yl)ethanone

: 1318898-60-0
methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; pyridinium hydrobromide perbromide / 0.17 h

1.2: 4 h

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.2: 110 °C / Sealed tube

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

4.2: 2 h

4.3: 2 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 5773-80-8
6-bromo-2-naphthoic acid

: 1318898-60-0
methyl {(1S)-1-[((2S,4S)-2-{5-[6-(2-{(2S,4S)-1-[(2R)-2-(dimethylamino)-2-phenylacetyl]-4-methyl-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}-4-methyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12.08 h / 0 - 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 14 h / 0 - 20 °C

3.2: 0.17 h

4.1: acetic acid; pyridinium hydrobromide perbromide / 0.17 h

4.2: 4 h

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.2: 110 °C / Sealed tube

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

7.2: 2 h

7.3: 2 h / 80 °C

8.1: hydrogenchloride / 1,4-dioxane / 1.5 h

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;