3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

Base Information

Chemical Name:3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide
CAS No.:507271-76-3
Molecular Formula:C₁₆H₁₂F₂N₂O₃S₂
Molecular Weight:382.412
Hs Code.:

Synonyms:3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

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Chemical Property of 3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

Chemical Property:

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Technology Process of 3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

There total 8 articles about 3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 507272-17-5
3-(2,4-difluorophenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester

: 507271-76-3
3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

Guidance literature:: With LiOH; ammonia; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;

Reference yield:

: 3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonyl chloride

: 507271-76-3
3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

Guidance literature:: With ammonia; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2004.06.075

Reference yield:

: 1996-44-7
2,4-difluorothiophenol

: 507271-76-3
3-(2,4-difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: [bis(trifluoroacetoxy)iodo]benzene / various solvent(s)

2: aq. LiOH / tetrahydrofuran

3: oxalyl chloride; DMF / CH₂Cl₂

4: NH₃ / dioxane

With lithium hydroxide; oxalyl dichloride; ammonia; N,N-dimethyl-formamide; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2004.06.075