2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

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Chemical Name:2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone
CAS No.:113522-65-9
Molecular Formula:C₂₉H₄₀O₃Si
Molecular Weight:464.72
Hs Code.:

Synonyms:2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

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Chemical Property of 2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

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Technology Process of 2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

There total 6 articles about 2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 113522-64-8
2-[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-butyl]-6,6-dimethyl-cyclohex-2-enone

: 113522-65-9
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4039(00)96293-2

Reference yield:

: 77661-80-4
2-(2-(benzyloxy)ethyl)propane-1,3-diol

: 113522-65-9
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / Bu₂SnO (stannylene acetal) Bu₄NBr / toluene / 18 h / Heating

2: 92 percent / Ph₃P, imidazole, I₂ / tetrahydrofuran / 1 h / 20 °C

3: 2.) p-TsOH / 1.) THF, -78 deg C to 20 deg C, 5h; 2.) 5h, 20 deg C

4: Et₃N / methanol / 12 h / 20 °C

5: 71 percent / boron tribromide / CH₂Cl₂ / 0.25 h / 0 °C

With 1H-imidazole; Bu₂SnO (stannylene acetal) Bu₄NBr; iodine; boron tribromide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)96293-2

Reference yield:

: 113522-59-1
CH(CH₂CH₂OBn)(CO₂Me)2

: 113522-65-9
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / BH₃ - dimethyl sulfide / tetrahydrofuran / 9 h / 75 °C

2: 92 percent / Bu₂SnO (stannylene acetal) Bu₄NBr / toluene / 18 h / Heating

3: 92 percent / Ph₃P, imidazole, I₂ / tetrahydrofuran / 1 h / 20 °C

4: 2.) p-TsOH / 1.) THF, -78 deg C to 20 deg C, 5h; 2.) 5h, 20 deg C

5: Et₃N / methanol / 12 h / 20 °C

6: 71 percent / boron tribromide / CH₂Cl₂ / 0.25 h / 0 °C

With 1H-imidazole; dimethylsulfide borane complex; Bu₂SnO (stannylene acetal) Bu₄NBr; iodine; boron tribromide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)96293-2