4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

Base Information

Chemical Name:4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester
CAS No.:113522-72-8
Molecular Formula:C₃₀H₄₀O₄Si
Molecular Weight:492.731
Hs Code.:

Synonyms:4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

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Chemical Property of 4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

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Technology Process of 4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

There total 8 articles about 4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 113522-69-3
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

: 113522-72-8
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

Guidance literature:: In methanol; diethyl ether; at 20 ℃;
DOI:10.1016/S0040-4039(00)96293-2

Reference yield:

: 77661-80-4
2-(2-(benzyloxy)ethyl)propane-1,3-diol

: 113522-72-8
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / Bu₂SnO (stannylene acetal) Bu₄NBr / toluene / 18 h / Heating

2: 92 percent / Ph₃P, imidazole, I₂ / tetrahydrofuran / 1 h / 20 °C

3: 2.) p-TsOH / 1.) THF, -78 deg C to 20 deg C, 5h; 2.) 5h, 20 deg C

4: Et₃N / methanol / 12 h / 20 °C

5: 71 percent / boron tribromide / CH₂Cl₂ / 0.25 h / 0 °C

6: Jones reagent / acetone / 1 h / 20 °C

7: 85 percent / diethyl ether; methanol / 20 °C

With 1H-imidazole; jones reagent; Bu₂SnO (stannylene acetal) Bu₄NBr; iodine; boron tribromide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(00)96293-2

Reference yield:

: 113522-59-1
CH(CH₂CH₂OBn)(CO₂Me)2

: 113522-72-8
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / BH₃ - dimethyl sulfide / tetrahydrofuran / 9 h / 75 °C

2: 92 percent / Bu₂SnO (stannylene acetal) Bu₄NBr / toluene / 18 h / Heating

3: 92 percent / Ph₃P, imidazole, I₂ / tetrahydrofuran / 1 h / 20 °C

4: 2.) p-TsOH / 1.) THF, -78 deg C to 20 deg C, 5h; 2.) 5h, 20 deg C

5: Et₃N / methanol / 12 h / 20 °C

6: 71 percent / boron tribromide / CH₂Cl₂ / 0.25 h / 0 °C

7: Jones reagent / acetone / 1 h / 20 °C

8: 85 percent / diethyl ether; methanol / 20 °C

With 1H-imidazole; jones reagent; dimethylsulfide borane complex; Bu₂SnO (stannylene acetal) Bu₄NBr; iodine; boron tribromide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(00)96293-2