3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

Base Information

Chemical Name:3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one
CAS No.:1333147-73-1
Molecular Formula:C₃₃H₂₉NO₃
Molecular Weight:487.598
Hs Code.:

Synonyms:3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

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Chemical Property of 3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

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Technology Process of 3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

There total 9 articles about 3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1333147-71-9
3-(benzyloxy)-5-bromo-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

: 5122-95-2
3-Biphenylboronic acid

: 1333147-73-1
3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 155 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 129611-32-1
2-bromo-6-iodopyridin-3-ol

: 1333147-73-1
3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / methanol / 50 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

2.2: 1 h / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: potassium carbonate / methanol / 48 h / 20 °C

5.1: bromine / acetic acid / 20 °C

6.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

6.2: 20 °C

7.1: tetrahydrofuran / 1 h / 0 °C

8.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 155 °C / Microwave irradiation

With bromine; isopropylmagnesium chloride; sodium hydride; sodium carbonate; potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1333147-73-1
3-(benzyloxy)-5-(biphenyl-3-yl)-6-(1-hydroxy-2-phenylethyl)-1-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: iodine; potassium carbonate / water / 20 °C

2.1: potassium carbonate / methanol / 50 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

3.2: 1 h / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: potassium carbonate / methanol / 48 h / 20 °C

6.1: bromine / acetic acid / 20 °C

7.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

7.2: 20 °C

8.1: tetrahydrofuran / 1 h / 0 °C

9.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 155 °C / Microwave irradiation

With bromine; iodine; isopropylmagnesium chloride; sodium hydride; sodium carbonate; potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;