tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate
CAS No.:1412978-43-8
Molecular Formula:C₂₅H₃₂N₂O₄
Molecular Weight:424.54
Hs Code.:

Synonyms:tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

There total 3 articles about tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879275-54-4
tert-butyl (R)-3-(N-benzyloxycarbonyl)aminomethylpyrrolidine-1-carboxylate

: 100-39-0
benzyl bromide

: 1412978-43-8
tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl (R)-3-(N-benzyloxycarbonyl)aminomethylpyrrolidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 70 ℃;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1412978-43-8
tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / -5 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 70 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 199174-29-3
tert-butyl (R)-3-(aminomethyl)pyrrolidine-1-carboxylate

: 1412978-43-8
tert-butyl (S)-3-[N-benzyl-N-(benzyloxycarbonyl)aminomethyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / -5 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 70 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;