1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

Base Information

Chemical Name:1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil
CAS No.:113808-29-0
Molecular Formula:C₂₃H₂₉N₂O₁₀P
Molecular Weight:524.464
Hs Code.:

Synonyms:1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

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Technology Process of 1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

There total 16 articles about 1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 113808-27-8
1,2-di-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-D-ribo-hexofuranose

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 124572-50-5
3-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

: 113808-29-0
1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

Guidance literature:: With tin(IV) chloride; In 1,2-dichloro-ethane; acetonitrile; at 20 ℃; for 16h;

Reference yield: 36.0%

: 113808-27-8
1,2-di-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-D-ribo-hexofuranose

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 6490-42-2
N-1-ethyluracil

: 113808-29-0
1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 16h;

Reference yield:

: 7057-09-2
1,2-O-isopropylidene-5-deoxy-α-D-glucofuranose

: 113808-29-0
1-(2-O-acetyl-3-O-benzoyl-5,6-dideoxy-6-diethylphosphono-β-D-ribo-hexofuranosyl)uracil

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / pyridine / 24 h / 20 °C

2: 1)dimethyl sulfoxide/acetic anhydride, 2)sodium borohydride / 1)1.5h, 70 deg C, 2)1h, room temperature

3: 85 percent / triethylamine / dioxane / 1 h / 20 °C

4: 89 percent / tin tetrachloride / 1,2-dichloro-ethane / 0.08 h / 20 °C

5: 78 percent / triphenylphosphine/carbon tetrabromide / dimethylformamide / 16 h / 20 °C

6: 100 percent / 4 h / Heating

7: sulfuric acid / acetic acid / 18 h / 20 °C

8: 30 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 16 h / 20 °C

With pyridine; sodium tetrahydroborate; carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; acetic anhydride; tin(IV) chloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In 1,4-dioxane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;