6490-42-2

Basic information

• Product Name: 1-ETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
• Synonyms: 1-Ethyluracil
• CAS NO: 6490-42-2
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.13992
• Mol File: 6490-42-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Density: 1.193 g/cm³
• Refractive Index: 1.5
• CAS DataBase Reference: 1-ETHYLPYRIMIDINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYLPYRIMIDINE-2,4(1H,3H)-DIONE(6490-42-2)
• EPA Substance Registry System: 1-ETHYLPYRIMIDINE-2,4(1H,3H)-DIONE(6490-42-2)

Safety Data

• Hazardous Substances Data: 6490-42-2(Hazardous Substances Data)

Usage

General Description

1-Ethylpyrimidine-2,4(1H,3H)-dione, also known as Aminoguanidine acetate, is a chemical compound with the molecular formula C6H8N2O2. It is an organic building block used in the synthesis of pharmaceutical compounds and agrochemicals. 1-ETHYLPYRIMIDINE-2,4(1H,3H)-DIONE has been studied for its potential as an antidiabetic and antiglycation agent, as well as for its antimicrobial and antioxidant properties. 1-Ethylpyrimidine-2,4(1H,3H)-dione has also been investigated for its potential to inhibit the formation of advanced glycation end products, which are associated with diabetic complications. 1-ETHYLPYRIMIDINE-2,4(1H,3H)-DIONE has shown promise as a therapeutic agent for various medical conditions, and further research is ongoing to explore its potential applications in medicine and agriculture.

InChI:InChI=1/C6H8N2O2/c1-2-8-4-3-5(9)7-6(8)10/h3-4H,2H2,1H3,(H,7,9,10)

Upstream product

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• 10457-14-4 O,O'-bis-(trimethylsilyl)uracil 
• 71-30-7 Cytosine 
• 75-04-7 ethylamine 
• 25855-36-1 1-ethyl-4-(methylsulfanyl)pyrimidin-2(1H)-one 
• 18002-25-0 4-methoxy-2-pyrimidone 
• 64-67-5 diethyl sulfate 
• 64-17-5 ethanol 

Relevant articles and documents

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Triphenylphosphine-free approach for one-pot N-alkylation of purine, pyrimidine, and azole derivatives with alcohols using P2O5/KI: A facile and selective route to access carboacyclic nucleosides

A facile, selective, and mild synthetic approach for one-pot N-alkylation of nucleobases and other related N-heterocycles via alcohols, using a mixture of P2O5 and KI is described. The reaction of structurally diverse purines, pyrimidines, and/or azoles with primary alcohols with the use of P2O5/KI and basic mixture of Et3N/K2CO3 in refluxing DMF affords the corresponding N-alkyl derivatives (carboacyclic nucleosides) in good to reasonable yields. The influence of different parameters comprising solvent, base, temperature, and substrate/reagent ratios was assessed on the reaction progress. The secondary and tertiary alcohols were failed to react with nucleobases. The main advantageous of current protocol is formation of water soluble side products in which provides simple work-up and purification processes.

A diversity of alkylation/acylation products of uracil and its derivatives: Synthesis and a structural study

tert-Butyl dicarbonate (Boc2O) and ethyl iodide (EtI) reactions with uracil (U), thymine (T) and 6-methyluracil (6-MU) were performed following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the molecular structure of all uracil derivatives. Parallel quantum mechanical DFT calculations supported the experimental findings.