N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide
CAS No.:639863-76-6
Molecular Formula:C₂₆H₃₁F₄N₃O₃
Molecular Weight:509.544
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

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Chemical Property of N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

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Technology Process of N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

There total 7 articles about N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 639863-75-5
1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene

: 639863-74-4
N-(4-fluorobenzyl)-1-(trifluoroacetyl)piperidin-4-amine

: 639863-76-6
N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

Guidance literature:: In dichloromethane; for 20h;

Reference yield:

: 65220-86-2
1-(trifluoroacetyl)-4-piperidone

: 639863-76-6
N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 0.08 h / pH 5

1.2: 20 h / 20 °C

2.1: dichloromethane / 20 h

With acetic acid; In methanol; dichloromethane;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 639863-76-6
N-(4-fluorobenzyl)-N-[1-(trifluoroacetyl)piperidin-4-yl]-N'-(4-isobutyloxybenzyl)carbamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

1.2: 72 h / 80 °C

2.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / tetrahydrofuran / 0.25 h

2.2: 4 h / Heating / reflux

3.1: dichloromethane / 20 h

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;