Technology Process of methyl 5-bromo-2,3-dimethoxyphenylacetate
There total 11 articles about methyl 5-bromo-2,3-dimethoxyphenylacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfuric acid;
In
1,2-dichloro-ethane;
for 15h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / NaBH4 / propan-2-ol / 1 h / Heating
2: 83 percent / SOCl2 / diethyl ether / 2 h / Heating
3: 95 percent / various solvent(s) / 2 h / 100 °C
4: 75 percent / KOH / aq. ethanol / 10 h / Heating
5: 76 percent / conc. H2SO4 / 1,2-dichloro-ethane / 15 h / Heating
With
potassium hydroxide; sodium tetrahydroborate; thionyl chloride; sulfuric acid;
In
diethyl ether; ethanol; 1,2-dichloro-ethane; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) NaNO2, conc. H2SO4, 2) copper powder, CuSO4*5H2O, NaBr, conc. H2SO4 / 1) water, 1-5 deg C, 2) water, reflux, 3 h, then distillation with steam
2: 51 percent / KMnO4 / H2O / 10 h / Heating
3: SOCl2 / 2 h / Heating
4: diethyl ether / 10 h / 20 °C
5: 57 percent / silver oxide / dioxane; H2O / 1 h / 95 °C
6: 76 percent / conc. H2SO4 / 1,2-dichloro-ethane / 15 h / Heating
With
potassium permanganate; thionyl chloride; sulfuric acid; copper; copper(II) sulfate; sodium bromide; silver(l) oxide; sodium nitrite;
In
1,4-dioxane; diethyl ether; water; 1,2-dichloro-ethane;
