4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

Base Information

Chemical Name:4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide
CAS No.:898552-45-9
Molecular Formula:C₂₄H₂₇ClN₄O₃S
Molecular Weight:487.022
Hs Code.:

Synonyms:4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

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Chemical Property of 4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

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Technology Process of 4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

There total 11 articles about 4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₆Cl₂N₂O₃S

: 108-00-9
N,N-dimethylethylenediamine

: 898552-45-9
4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

Guidance literature:: With triethylamine; In dichloromethane; for 1h;

Reference yield:

: 130912-54-8
3,3-dimethyl-4-nitro-butyric acid ethyl ester

: 898552-45-9
4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 110 °C / 3344.22 Torr

2: hydrogenchloride; water / 20 h / 120 °C

3: ethanol / 16 h / 85 °C / Heating / reflux

4: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

5: potassium carbonate / 6 h / 120 °C

6: trifluoroacetic acid / water / 16 h / 90 °C

7: oxalyl dichloride / pyridine / dichloromethane / 1 h / 20 °C

8: triethylamine / dichloromethane / 1 h

With hydrogenchloride; oxalyl dichloride; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; pyridine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; chloroform; water;

Reference yield:

: 898552-72-2
ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride

: 898552-45-9
4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-N-(2-dimethylamino-ethyl)-3,3-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

2: potassium carbonate / 6 h / 120 °C

3: trifluoroacetic acid / water / 16 h / 90 °C

4: oxalyl dichloride / pyridine / dichloromethane / 1 h / 20 °C

5: triethylamine / dichloromethane / 1 h

With oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; pyridine; In dichloromethane; chloroform; water;