3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide
CAS No.:186837-48-9
Molecular Formula:C₁₃H₂₁IO₂Si
Molecular Weight:364.299
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

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Technology Process of 3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

There total 3 articles about 3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 160257-85-2
5-iodo-2-methoxyphenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 186837-48-9
3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;
DOI:10.1021/jo9704220

Reference yield:

: 183593-98-8
5-iodo-2-methoxyphenyl acetate

: 186837-48-9
3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / potassium carbonate / methanol / 16 h / 18 °C

2: 84 percent / imidazole / dimethylformamide / 16 h / 0 - 18 °C

With 1H-imidazole; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.02.018

Reference yield:

: 179902-22-8
1-acetoxy-4-iodo-2-methoxy-benzene

: 186837-48-9
3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 3.5 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C / Cooling with ice

With 1H-imidazole; lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1290899