2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

Base Information

Chemical Name:2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester
CAS No.:1396762-89-2
Molecular Formula:C₂₃H₂₆N₂O₈
Molecular Weight:458.468
Hs Code.:

Synonyms:2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

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Chemical Property of 2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

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Technology Process of 2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

There total 1 articles about 2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 10565-14-7
Diethyl 2-(2-nitrophenyl)propanedioate

: 1215021-54-7
benzyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

: 1396762-89-2
2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

Guidance literature:: Diethyl 2-(2-nitrophenyl)propanedioate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;

benzyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide; In tetrahydrofuran; mineral oil; for 48h; Inert atmosphere; Reflux;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z

Reference yield: 86.0%

: 1396762-89-2
2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

: 1396762-91-6
3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z

Reference yield: 73.0%

: 1396762-89-2
2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester

: 74-88-4
methyl iodide

: 1396762-92-7
ethyl 1-methyl-3-(2-nitrophenyl)-2-oxopyrrolidine-3-carboxylate

Guidance literature:: 2-(2-benzyloxycarbonylaminoethyl)-2-(2-nitrophenyl)-malonic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol302176z DOI:10.1021/ol302176z