trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

Base Information

Chemical Name:trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid
CAS No.:1260585-96-3
Molecular Formula:C₁₂H₁₄BrN₅O₂
Molecular Weight:340.179
Hs Code.:

Synonyms:trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

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Chemical Property of trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

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Technology Process of trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

There total 6 articles about trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1260585-95-2
trans-4-(5-bromo-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid methyl ester

: 1260585-96-3
trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

Guidance literature:: trans-4-(5-bromo-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid methyl ester; With 1,2,4-Triazole; trichlorophosphate; In pyridine; at 10 - 40 ℃; Industry scale;

With ammonia; In pyridine; ethanol; at -15 - 0 ℃; Industry scale;

Reference yield:

: 103-49-1
dibenzylamine

: 1260585-96-3
trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethyl acetate / 60 - 80 °C / Industry scale

1.2: 24 h / Reflux; Industry scale

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 55 °C / Industry scale; Inert atmosphere

2.2: Industry scale

2.3: 50 °C / Industry scale

3.1: trichlorophosphate / acetonitrile / Reflux; Industry scale

3.2: 1 h / 0 - 30 °C / pH 8 / Industry scale

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 - 37 °C / Industry scale

5.1: tert.-butylnitrite / tetrahydrofuran / 15 - 25 °C / Industry scale

6.1: trichlorophosphate; 1,2,4-Triazole / pyridine / 10 - 40 °C / Industry scale

6.2: -15 - 0 °C / Industry scale

With 1,2,4-Triazole; N-Bromosuccinimide; tert.-butylnitrite; hydrogen; acetic acid; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 93206-03-2
3-amino-6-((dibenzylamino)methyl)-1,2,4-triazine-5-(4H)-one

: 1260585-96-3
trans-4-(4-amino-5-bromoimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; acetic acid / palladium 10% on activated carbon / water / 55 °C / Industry scale; Inert atmosphere

1.2: Industry scale

1.3: 50 °C / Industry scale

2.1: trichlorophosphate / acetonitrile / Reflux; Industry scale

2.2: 1 h / 0 - 30 °C / pH 8 / Industry scale

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 - 37 °C / Industry scale

4.1: tert.-butylnitrite / tetrahydrofuran / 15 - 25 °C / Industry scale

5.1: trichlorophosphate; 1,2,4-Triazole / pyridine / 10 - 40 °C / Industry scale

5.2: -15 - 0 °C / Industry scale

With 1,2,4-Triazole; N-Bromosuccinimide; tert.-butylnitrite; hydrogen; acetic acid; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide; acetonitrile;