ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

Base Information

Chemical Name:ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate
CAS No.:1310808-18-4
Molecular Formula:C₂₄H₂₆N₄O₆
Molecular Weight:466.494
Hs Code.:

Synonyms:ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

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Chemical Property of ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

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Technology Process of ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

There total 8 articles about ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₀N₄O₆Si

: 1310808-18-4
ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 35120-18-4
ethyl 1-bromocyclobutane-1-carboxylate

: 1310808-18-4
ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 35 h / 80 - 120 °C

2.1: sodium hydroxide / ethanol; water / 4 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 50 °C

3.2: 0.5 h / Cooling with ice

4.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3000.3 Torr

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 - 120 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1310807-63-6
3-(benzyloxy)-5-{[1-(hydroxymethyl)cyclobutyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)benzamide

: 1310808-18-4
ethyl 5-(3-{[1-(hydroxymethyl)cyclobutyl]oxy}-5-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]phenoxy)pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3000.3 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 - 120 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;