tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

Base Information

Chemical Name:tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate
CAS No.:278593-20-7
Molecular Formula:C₂₆H₂₃IN₂O₅S
Molecular Weight:602.45
Hs Code.:

Synonyms:tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

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Chemical Property of tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

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Technology Process of tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

There total 3 articles about tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 278593-18-3
N-(2-Iodophenyl)-1-(phenylsulfonyl)-1H-indole-3-carboxamide

: 278593-20-7
tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

Guidance literature:: With dmap; triethylamine; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1055/s-2000-6374

Reference yield:

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 278593-20-7
tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / NaClO₂; H₂O; sulfamic acid / dioxane / 20 °C

2: 82 percent / DMAP; EDCI*HCl / CH₂Cl₂ / 20 °C

3: 97 percent / DMAP; Et₃N / acetonitrile / 16 h / 20 °C

With dmap; sodium chlorite; aminosulfonic acid; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile; 1: Oxidation / 2: Acylation / 3: Acylation;
DOI:10.1055/s-2000-6374

Reference yield:

: 278593-17-2
1-(phenylsulfonyl)-1H-indole-3-carboxylic acid

: 278593-20-7
tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / DMAP; EDCI*HCl / CH₂Cl₂ / 20 °C

2: 97 percent / DMAP; Et₃N / acetonitrile / 16 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile; 1: Acylation / 2: Acylation;
DOI:10.1055/s-2000-6374