278593-17-2

Basic information

• Product Name: 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BE 1326;1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID;1-PHENYLSULPHONYLINDOLE-3-CARBOXYLIC ACID;1-(Phenylsulphonyl)indole-3-carboxylic acid 97%;1-(Phenylsulphonyl)indole-3-carboxylicacid97%;1-(phenylsulfonyl)-3-indolecarboxylic acid;1-(Phenylsulphonyl)-1H-indole-3-carboxylic acid 97%;3-Carboxy-1-(phenylsulphonyl)-1H-indole, 3-Carboxy-1H-indol-1-yl phenyl sulphone
• CAS NO: 278593-17-2
• Molecular Formula: C₁₅H₁₁NO₄S
• Molecular Weight: 301.32
• Mol File: 278593-17-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 232 °C
• Boiling Point: 570.7°Cat760mmHg
• Flash Point: 299°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 7.27E-14mmHg at 25°C
• Refractive Index: 1.663
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID(278593-17-2)
• EPA Substance Registry System: 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID(278593-17-2)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• HazardClass: IRRITANT
• Hazardous Substances Data: 278593-17-2(Hazardous Substances Data)

Usage

General Description

1-(Phenylsulfonyl)-1H-indole-3-carboxylic acid is a chemical compound with the molecular formula C16H13NO4S. It is a derivative of indole and contains a sulfonyl group and a carboxylic acid group. 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID is often used in the synthesis of pharmaceuticals and organic compounds. It has been studied for its potential therapeutic applications, particularly in the field of cancer treatment and anti-inflammatory drugs. The sulfonyl group in the molecule is known for its ability to modulate the biological activity of various compounds, making 1-(phenylsulfonyl)-1H-indole-3-carboxylic acid a valuable building block in medicinal chemistry and drug discovery.

InChI:InChI=1/C15H11NO4S/c17-15(18)13-10-16(14-9-5-4-8-12(13)14)21(19,20)11-6-2-1-3-7-11/h1-10H,(H,17,18)

Upstream product

• 771-50-6 1H-indole-3-carboxylic acid 
• 98-09-9 benzenesulfonyl chloride 
• 942-24-5 3-methoxycarbonylindole 
• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 

Downstream Products

• 278593-18-3 N-(2-Iodophenyl)-1-(phenylsulfonyl)-1H-indole-3-carboxamide 
• 923603-92-3 N-(2-iodobenzyl)-1-(phenylsulfonyl)-1H-indole-3-carboxamide 
• 1450651-85-0 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(phenylsulfonyl)-1H-indole-3-carboxamide 
• 99655-68-2 3-bromo-1-phenylsulfonyl indole 
• 145662-43-7 2,3-Dibromo-1-(phenylsulfonyl)indole 
• 1160939-81-0 3,5-diamino-6-chloropyrazine-2-carboxylic acid [8-(1-benzenesulfonyl-1H-indole-3-carbonyl)-1,3,8-triazaspiro[4.5]dec-(2E)-ylidene]-amide 
• 701205-85-8 (1-benzenesulfonyl-1H-indol-3-yl)-(4-methylpiperazin-1-yl)methanone 
• 278593-25-2 11-(Phenylsulfonyl)-11H-indolo[3,2-c]quinolin-6-yl trifluoromethanesulfonate 
• 278593-20-7 tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate 
• 278593-22-9 11-(Phenylsulfonyl)-6,11-dihydro-5H-indolo[3,2-c]quinolin-6-one 
• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 
• 615574-44-2 {2-[2-(1-benzenesulfonyl-1H-indole-3-carbonyl)-1H-indol-3-yl]-ethyl}-carbamic acid benzyl ester 

Relevant articles and documents

17 BETA HSD TYPE 5 INHIBITOR

To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone; and the present invention has thus been completed.

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.

Synthesis of indolo[3,2-c]quinoline and pyrido[3',2':4,5][3,2- c]quinoline derivatives

Potential antitumoral scaffold indolo[3,2-c]quinoline 5a was obtained by an intramolecular Heck cyclisation from the corresponding 2-iodophenyl-3- indolecarboxamide 4a. The 7-azaindole analogue 5b was prepared by the same approach. Triflate displacement o