278593-17-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(Phenylsulfonyl)-1H-indole-3-carboxylic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to modulate biological activity, enhancing the efficacy of drug candidates.
Used in Cancer Treatment Research:
In the field of oncology, 1-(Phenylsulfonyl)-1H-indole-3-carboxylic acid is studied for its potential as a therapeutic agent, particularly for its role in modulating signaling pathways associated with cancer cell growth and proliferation.
Used in Anti-inflammatory Drug Development:
1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID is also utilized in the development of anti-inflammatory drugs, capitalizing on its structural features to potentially alleviate inflammation by modulating immune responses.
Used in Medicinal Chemistry:
1-(Phenylsulfonyl)-1H-indole-3-carboxylic acid serves as a valuable building block in medicinal chemistry, contributing to the design and synthesis of novel compounds with improved pharmacological properties.
Used in Drug Discovery:
In drug discovery processes, 1-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXYLIC ACID is employed for its potential to contribute to the creation of new drug candidates, especially those targeting specific biological pathways or receptors.

InChI:InChI=1/C15H11NO4S/c17-15(18)13-10-16(14-9-5-4-8-12(13)14)21(19,20)11-6-2-1-3-7-11/h1-10H,(H,17,18)

Upstream product

• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 
• 771-50-6 1H-indole-3-carboxylic acid 
• 98-09-9 benzenesulfonyl chloride 
• 942-24-5 3-methoxycarbonylindole 

Downstream Products

• 278593-18-3 N-(2-Iodophenyl)-1-(phenylsulfonyl)-1H-indole-3-carboxamide 
• 99532-51-1 1-phenylsulfonylindol-3-ylcarboxylic acid chloride 
• 858515-49-8 C₃₇H₄₃N₃O₇S 
• 459869-42-2 Se-phenyl 1-(phenylsulfonyl)-3-indolecarboselenoate 
• 923603-92-3 N-(2-iodobenzyl)-1-(phenylsulfonyl)-1H-indole-3-carboxamide 
• 869985-78-4 12-(phenylsulfonyl)-7-oxo-5,6,7,12-tetrahydroindolo[3,2-d][2]benzazepine-6-carboxylic acid tert-butyl ester 
• 869985-64-8 tert-butyl (2-iodobenzyl){[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate 
• 1026229-98-0 1-(1-benzenesulfonyl-1H-indol-3-yl)-4,9-dihydro-3H-β-carboline 
• 615574-45-3 1-benzenesulfonyl-1H-indole-3-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide 
• 615574-44-2 {2-[2-(1-benzenesulfonyl-1H-indole-3-carbonyl)-1H-indol-3-yl]-ethyl}-carbamic acid benzyl ester 
• 80360-20-9 1-(phenylsulfonyl)indole-3-carbaldehyde 
• 278593-22-9 11-(Phenylsulfonyl)-6,11-dihydro-5H-indolo[3,2-c]quinolin-6-one 
• 278593-20-7 tert-Butyl N-(2-iodophenyl)-N-{[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl}carbamate 
• 278593-25-2 11-(Phenylsulfonyl)-11H-indolo[3,2-c]quinolin-6-yl trifluoromethanesulfonate 

Relevant academic research and scientific papers

17 BETA HSD TYPE 5 INHIBITOR

To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone; and the present invention has thus been completed.

Synthesis and biological evaluation of bengacarboline derivatives

Novel derivatives of the marine alkaloid bengacarboline have been synthesized. The seco derivatives 11 and 12 were evaluated for topoisomerase inhibition, DNA damages, cytotoxicity and cell cycle perturbation. The two synthetic analogs are more potent cyt

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.

First synthesis of marine alkaloid (±)-bengacarboline

Bengacarboline 1, a marine alkaloid, potent inhibitor of topoisomerase II, has been synthesized in nine steps from indol-3-carboxylic acid and tryptamine.

Synthesis of indolo[3,2-c]quinoline and pyrido[3',2':4,5][3,2- c]quinoline derivatives

Potential antitumoral scaffold indolo[3,2-c]quinoline 5a was obtained by an intramolecular Heck cyclisation from the corresponding 2-iodophenyl-3- indolecarboxamide 4a. The 7-azaindole analogue 5b was prepared by the same approach. Triflate displacement o