(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

Base Information

Chemical Name:(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione
CAS No.:1308721-98-3
Molecular Formula:C₄₅H₅₂N₂O₁₄S
Molecular Weight:876.979
Hs Code.:

(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

Synonyms:(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

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Chemical Property of (3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

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Technology Process of (3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

There total 13 articles about (3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (3Z)-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonylxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

: 108-23-6
isopropyl chloroformate

: 1308721-98-3
(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 23h; Cooling with ice;
DOI:10.1016/j.tet.2012.03.105

Reference yield:

: 1308721-86-9
2-hydroxy-3-methyl-4,5-dimethoxybenzaldehyde

: 1308721-98-3
(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5.5 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 17 h / 25 °C

4.1: water; sodium hydrogencarbonate / ethanol / 2.5 h / Reflux

5.1: dmap; triethylamine / dichloromethane / 23 h / 25 °C

With dmap; potassium tert-butylate; water; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.055

Reference yield:

: 2033-89-8
3,4-dimethoxyphenol

: 1308721-98-3
(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 0 °C

2.1: hydrogenchloride / ethanol; water

3.1: acetic acid

4.1: triethylamine / dichloromethane / 0 °C

5.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5.5 h

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 17 h / 25 °C

7.1: water; sodium hydrogencarbonate / ethanol / 2.5 h / Reflux

8.1: dmap; triethylamine / dichloromethane / 23 h / 25 °C

With hydrogenchloride; dmap; n-butyllithium; potassium tert-butylate; water; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2011.02.055