1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Base Information

Chemical Name:1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione
CAS No.:1395839-80-1
Molecular Formula:C₂₃H₂₁N₃O₂S₂
Molecular Weight:435.571
Hs Code.:

Synonyms:1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Suppliers and Price of 1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

There total 4 articles about 1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 5217-47-0
N,N'-diethyl-2-thiobarbituric acid

: 1395839-73-2
1-(4-(thiophen-2-yl)phenyl)-1H-pyrrole-2-carbaldehyde

: 1395839-80-1
1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Guidance literature:: With triethylamine; In dichloromethane; for 5h; Reflux;
DOI:10.1016/j.tet.2012.07.082

Reference yield:

: 5044-39-3
1-(4-bromophenyl)-1H-pyrrole

: 1395839-80-1
1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

2.1: trichlorophosphate / 0.25 h / 0 °C

2.2: 4 h / 0 - 60 °C

3.1: triethylamine / dichloromethane / 5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; dichloromethane; 1.1: Suzuki coupling / 2.2: Vilsmeier formylation / 3.1: Knoevenagel condensation;
DOI:10.1016/j.tet.2012.07.082

Reference yield:

: 106-40-1
4-bromo-aniline

: 1395839-80-1
1,3-diethyl-dihydro-5-(((1-(4-thiophen-2-yl)phenyl)-1H-pyrrol-2-yl)methylene)-2-thioxopyrimidine-4,6(1H,5H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

3.1: trichlorophosphate / 0.25 h / 0 °C

3.2: 4 h / 0 - 60 °C

4.1: triethylamine / dichloromethane / 5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; dichloromethane; 1.1: Paal-Knorr pyrrole synthesis / 2.1: Suzuki coupling / 3.2: Vilsmeier formylation / 4.1: Knoevenagel condensation;
DOI:10.1016/j.tet.2012.07.082