ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

Base Information

Chemical Name:ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate
CAS No.:1430475-79-8
Molecular Formula:C₂₆H₂₄FN₃O₆S
Molecular Weight:525.557
Hs Code.:

Synonyms:ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

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Chemical Property of ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

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Technology Process of ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

There total 3 articles about ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 51264-70-1
ethyl 2-(4-formyl-2-methoxyphenoxy)acetate

: 1430475-73-2
1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)methanesulfonamide

: 1430475-79-8
ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

Guidance literature:: With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 135 ℃; for 1.5h; Sealed tube;
DOI:10.1016/j.bmcl.2013.02.109

Reference yield:

: 1430475-71-0
ethyl 2-[N-(4-fluorophenyl)sulfamoyl]acetate

: 1430475-79-8
ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / water / 16 h / 20 °C

2: Lawessons reagent / neat (no solvent) / 2 h / 150 °C / Sealed tube

3: chloro-trimethyl-silane / N,N-dimethyl-formamide / 1.5 h / 135 °C / Sealed tube

With Lawessons reagent; chloro-trimethyl-silane; potassium hydroxide; In water; N,N-dimethyl-formamide; 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.02.109

Reference yield:

: 904627-07-2
2-[N-(4-fluorophenyl)sulfamoyl]acetic acid

: 1430475-79-8
ethyl 2-(4-(2-(1H-benzo[d]imidazol-2-yl)-2-(N-(4-fluorophenyl)sulfamoyl)vinyl)-2-methoxyphenoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: Lawessons reagent / neat (no solvent) / 2 h / 150 °C / Sealed tube

2: chloro-trimethyl-silane / N,N-dimethyl-formamide / 1.5 h / 135 °C / Sealed tube

With Lawessons reagent; chloro-trimethyl-silane; In N,N-dimethyl-formamide; 2: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.02.109