51264-70-1Relevant articles and documents
A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG
Hernández-Montoto, Andy,Gorbe, Mónica,Llopis-Lorente, Antoni,Terrés, José Manuel,Montes, Roberto,Cao-Milán, Roberto,Díaz De Gre?u, Borja,Alfonso, María,Orzaez, Mar,Marcos, María Dolores,Martínez-Má?ez, Ramón,Sancenón, Félix
, p. 9039 - 9042 (2019)
Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorpti
3-hydroxycurcumin-4-OCH2CO2H strontium, and synthesis, activity and application thereof
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Paragraph 0012; 0014-0015, (2020/12/14)
The invention discloses 3-hydroxycurcumin-4-OCH2CO2H strontium, discloses a preparation method of the 3-hydroxycurcumin-4-OCH2CO2H strontium, and discloses anti-osteoporosis activity of the 3-hydroxycurcumin-4-OCH2CO2H strontium so that the invention disc
Janus Gold Nanostars–Mesoporous Silica Nanoparticles for NIR-Light-Triggered Drug Delivery
Hernández Montoto, Andy,Llopis-Lorente, Antoni,Gorbe, Mónica,M. Terrés, José,Cao-Milán, Roberto,Díaz de Gre?u, Borja,Alfonso, María,Iba?ez, Javier,Marcos, María D.,Orzáez, Mar,Villalonga, Reynaldo,Martínez-Má?ez, Ramón,Sancenón, Félix
, p. 8471 - 8478 (2019/07/16)
Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-β-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.