{2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol

Base Information

• Chemical Name: {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol
• CAS No.: 1175964-89-2
• Molecular Formula: C₁₄H₁₀Cl₂N₂O
• Molecular Weight: 293.152
• Mol file: 1175964-89-2.mol

Synonyms:{2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol

Chemical Property of {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol

There total 3 articles about {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (898389-45-2) → {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol (1175964-89-2)

Guidance literature:

2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde; With methanol; sodium tetrahydroborate; for 1.5h; Reflux;

In isopropyl alcohol; for 1.5h; Reflux;

DOI:10.1134/S1070428019090082

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(2,4-dichlorophenyl)-imidazo[1,2-a]pyridine (63111-80-8) → {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol (1175964-89-2)

Guidance literature:

formaldehyd; 2-(2,4-dichlorophenyl)-imidazo[1,2-a]pyridine; With sodium acetate; acetic acid; In water; at 50 ℃; for 6h;

With sodium hydroxide; In water;

Reference yield:

2-(2,4-dichlorophenyl)-imidazo[1,2-a]pyridine (63111-80-8) → {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol (1175964-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 11 h / 0 - 75 °C

2.1: sodium tetrahydroborate; methanol / 1.5 h / Reflux

2.2: 1.5 h / Reflux

With methanol; sodium tetrahydroborate; trichlorophosphate;

DOI:10.1134/S1070428019090082

upstream raw materials:

formaldehyd

2-(2,4-dichlorophenyl)-imidazo[1,2-a]pyridine

2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde