Technology Process of 3,17β-dihydroxy-17α-(2'-phenyl-1'-ethyn-1'-yl)estra-1,3,5(10)-triene
There total 3 articles about 3,17β-dihydroxy-17α-(2'-phenyl-1'-ethyn-1'-yl)estra-1,3,5(10)-triene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
tetrahydrofuran;
for 3h;
Heating;
DOI:10.1002/jlcr.709
- Guidance literature:
-
phenylacetylene;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
Estrone;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
at -78 - 20 ℃;
Further stages.;
DOI:10.1021/jm0001166
- Guidance literature:
-
With
copper(l) iodide; N-butylamine;
palladium;
Yield given. Multistep reaction;
DOI:10.1021/jm00095a006