C₂₁H₁₆FN₃

Base Information

Chemical Name:C₂₁H₁₆FN₃
CAS No.:1435770-07-2
Molecular Formula:C₂₁H₁₆FN₃
Molecular Weight:329.377
Hs Code.:

C<sub>21</sub>H<sub>16</sub>FN<sub>3</sub>

Synonyms:C₂₁H₁₆FN₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₆FN₃

Chemical Property:

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Technology Process of C₂₁H₁₆FN₃

There total 4 articles about C₂₁H₁₆FN₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1-(pyridin-4-yl)-2-(m-tolyl)ethane-1,2-dione

: 446-52-6
2-Fluorobenzaldehyde

: 1435770-07-2
C₂₁H₁₆FN₃

Guidance literature:: With ammonium acetate; copper(II) acetate monohydrate; In acetic acid; at 80 ℃;
DOI:10.1016/j.bmcl.2013.03.103

Reference yield:

: 1435769-89-3
4-(m-tolylethynyl)pyridine

: 1435770-07-2
C₂₁H₁₆FN₃

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; magnesium sulfate; potassium permanganate / acetone; water / -10 °C

2: ammonium acetate; copper(II) acetate monohydrate / acetic acid / 80 °C

With potassium permanganate; ammonium acetate; copper(II) acetate monohydrate; sodium hydrogencarbonate; magnesium sulfate; In water; acetic acid; acetone;
DOI:10.1016/j.bmcl.2013.03.103

Reference yield:

: 591-17-3
meta-bromotoluene

: 1435770-07-2
C₂₁H₁₆FN₃

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 192 h / 40 °C / Inert atmosphere

2: triethylamine; tetrabutyl ammonium fluoride / tetrahydrofuran / 48 h / 50 °C / Inert atmosphere

3: sodium hydrogencarbonate; magnesium sulfate; potassium permanganate / acetone; water / -10 °C

4: ammonium acetate; copper(II) acetate monohydrate / acetic acid / 80 °C

With potassium permanganate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; tetrabutyl ammonium fluoride; copper(II) acetate monohydrate; sodium hydrogencarbonate; magnesium sulfate; triethylamine; In tetrahydrofuran; water; acetic acid; acetone; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.03.103