5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS No.:1420468-59-2
Molecular Formula:C₁₄H₆Cl₄F₃N₃
Molecular Weight:415.029
Hs Code.:

Synonyms:5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

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Chemical Property of 5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

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Technology Process of 5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

There total 7 articles about 5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1420468-58-1
3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

: 1420468-59-2
5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With trichlorophosphate; at 0 - 110 ℃; for 5h; Inert atmosphere;

Reference yield:

: 39959-98-3
ethyl 2-cyano-3-(2,3-dichlorophenyl)propanoate

: 1420468-59-2
5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / methanol; water / 65 °C

2.1: 0.75 h / 180 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 5 h / -78 °C

4.1: hydrazine hydrate / ethanol / 16 h / Reflux

5.1: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

6.1: N,N-diethylaniline; trichlorophosphate / 3.25 h / 110 °C / Inert atmosphere

With sodium methylate; sodium carbonate; hydrazine hydrate; N,N-diethylaniline; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane; water;
DOI:10.1021/ml300330m

Reference yield:

: 39959-99-4
2-cyano-3-(2,3-dichlorophenyl)propanoic acid

: 1420468-59-2
5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.75 h / 180 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 5 h / -78 °C

3.1: hydrazine hydrate / ethanol / 16 h / Reflux

4.1: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

5.1: N,N-diethylaniline; trichlorophosphate / 3.25 h / 110 °C / Inert atmosphere

With sodium methylate; hydrazine hydrate; N,N-diethylaniline; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane;
DOI:10.1021/ml300330m