5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

Base Information

Chemical Name:5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol
CAS No.:1420468-60-5
Molecular Formula:C₁₄H₇Cl₃F₃N₃O
Molecular Weight:396.583
Hs Code.:

Synonyms:5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

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Chemical Property of 5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

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Technology Process of 5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

There total 8 articles about 5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1420468-59-2
5,7-dichloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

: 1420468-60-5
5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 45 ℃;

Reference yield:

: 1420468-58-1
3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

: 1420468-60-5
5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diethylaniline; trichlorophosphate / 3.25 h / 110 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

With N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water;
DOI:10.1021/ml300330m

Reference yield:

: 39959-98-3
ethyl 2-cyano-3-(2,3-dichlorophenyl)propanoate

: 1420468-60-5
5-chloro-3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / methanol; water / 65 °C

2.1: 0.75 h / 180 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 5 h / -78 °C

4.1: hydrazine hydrate / ethanol / 16 h / Reflux

5.1: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

6.1: N,N-diethylaniline; trichlorophosphate / 3.25 h / 110 °C / Inert atmosphere

7.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

With sodium methylate; sodium carbonate; hydrazine hydrate; N,N-diethylaniline; sodium hydroxide; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane; water;
DOI:10.1021/ml300330m