3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Base Information

Chemical Name:3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
CAS No.:1420468-58-1
Molecular Formula:C₁₄H₈Cl₂F₃N₃O₂
Molecular Weight:378.138
Hs Code.:

Synonyms:3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

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Chemical Property of 3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

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Technology Process of 3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

There total 6 articles about 3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2,3-dichlorobenzyl)-3-(trifluoromethyl)-1H-pyrazol-5-amine trifluoroacetate salt

: 108-59-8
malonic acid dimethyl ester

: 1420468-58-1
3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Guidance literature:: With sodium methylate; In methanol; at 20 - 80 ℃; Inert atmosphere;
DOI:10.1021/ml300330m

Reference yield:

: 39959-98-3
ethyl 2-cyano-3-(2,3-dichlorophenyl)propanoate

: 1420468-58-1
3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / methanol; water / 65 °C

2.1: 0.75 h / 180 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 5 h / -78 °C

4.1: hydrazine hydrate / ethanol / 16 h / Reflux

5.1: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

With sodium methylate; sodium carbonate; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; water;
DOI:10.1021/ml300330m

Reference yield:

: 39959-99-4
2-cyano-3-(2,3-dichlorophenyl)propanoic acid

: 1420468-58-1
3-[(2,3-dichlorophenyl)methyl]-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.75 h / 180 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 5 h / -78 °C

3.1: hydrazine hydrate / ethanol / 16 h / Reflux

4.1: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

With sodium methylate; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane;
DOI:10.1021/ml300330m