2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

Base Information

Chemical Name:2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)
CAS No.:1335300-42-9
Molecular Formula:C₂₂H₂₂FN₇O₃
Molecular Weight:451.46
Hs Code.:

Synonyms:2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

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Chemical Property of 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

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Technology Process of 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

There total 10 articles about 2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1335300-44-1
5-{2-[3-(2-Fluoro-ethoxy)-phenyl]-imidazol[1,2-a]pyrimidin-7-ylcarbamoyl}-1-methyl-1H-pyrazole-4-carboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1335300-42-9
2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 0 - 20 ℃;

Reference yield:

: 1335299-55-2
2-(3-methoxy-phenyl)-imidazo[1,2-a]pyrimidin-7-ylamine

: 1335300-42-9
2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide / water / 48 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 23 h / 70 °C / sealed tube

3.1: N-ethyl-N,N-diisopropylamine / 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

4.1: ethanol / tetrahydrofuran / 6 h / 20 °C

4.2: 0.5 h / pH 3

5.1: N-ethyl-N,N-diisopropylamine / 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

With ethanol; hydrogen bromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1335300-03-2
2-[3-(2-Fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-ylamine

: 1335300-42-9
2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-dimethylamide 3-({2-[3-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyrimidin-7-yl}-amide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

2.1: ethanol / tetrahydrofuran / 6 h / 20 °C

2.2: 0.5 h / pH 3

3.1: N-ethyl-N,N-diisopropylamine / 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

With ethanol; N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate;