10-(4-ethynylphenyl)-10H-phenothiazine

Base Information

• Chemical Name: 10-(4-ethynylphenyl)-10H-phenothiazine
• CAS No.: 262861-82-5
• Molecular Formula: C₂₀H₁₃NS
• Molecular Weight: 299.396
• Mol file: 262861-82-5.mol

Synonyms:10-(4-ethynylphenyl)-10H-phenothiazine

Chemical Property of 10-(4-ethynylphenyl)-10H-phenothiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-(4-ethynylphenyl)-10H-phenothiazine

There total 7 articles about 10-(4-ethynylphenyl)-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

10-{4-[(trimethylsilyl)ethynyl]phenyl}-10H-phenothiazine (1616858-37-7) → 10-(4-ethynylphenyl)-10H-phenothiazine (262861-82-5)

Guidance literature:

With methanol; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja5040073

Reference yield:

10-(4 -bromophenyl)-10H-phenothiazine (63524-03-8) → 10-(4-ethynylphenyl)-10H-phenothiazine (262861-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 15 h / Inert atmosphere; Reflux

2: potassium carbonate; methanol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;

DOI:10.1021/ja5040073

Reference yield:

10H-phenothiazine (92-84-2) → 10-(4-ethynylphenyl)-10H-phenothiazine (262861-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; copper(ll) sulfate pentahydrate / 15 h / 220 °C / Inert atmosphere

2: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 15 h / Inert atmosphere; Reflux

3: potassium carbonate; methanol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1: |Ullmann Condensation / 2: |Sonogashira Cross-Coupling;

DOI:10.1021/ja5040073

upstream raw materials:

1,4-bromoiodobenzene

10-{4-[(trimethylsilyl)ethynyl]phenyl}-10H-phenothiazine

10-(4 -bromophenyl)-10H-phenothiazine

10H-phenothiazine