[4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

Base Information

Chemical Name:[4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone
CAS No.:1163132-87-3
Molecular Formula:C₂₄H₂₆FN₃O₃S
Molecular Weight:455.553
Hs Code.:

Synonyms:[4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

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Chemical Property of [4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

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Technology Process of [4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

There total 7 articles about [4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82782-85-2
thieno<3,2-b>pyrrole-5-carboxylic acid methyl ester

: 1163132-87-3
[4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; 16-Crown-5 / N,N-dimethyl-formamide / 4 h / 80 - 90 °C

2.1: potassium hydroxide / methanol / 3 h / boiling

2.2: pH 3

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 3 h / 60 - 100 °C

4.1: potassium hydroxide / methanol / 3 h / Boiling

4.2: pH 3

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 7 h / 80 °C / Inert atmosphere

With potassium carbonate; 16-Crown-5; 1,1'-carbonyldiimidazole; potassium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 903165-55-9
C₂₀H₁₉FN₂O₃S

: 1163132-87-3
[4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 80 ℃; for 7h; Inert atmosphere;

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 1163132-87-3
[4-(4-Fluorobenzyl)-4H-thieno[3,2-b]pyrrol-5-yl][4-(morpholine-4-carbonyl)piperidin-1-yl]methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / 15 h / -10 - 0 °C

2.1: toluene

3.1: potassium carbonate; 16-Crown-5 / N,N-dimethyl-formamide / 4 h / 80 - 90 °C

4.1: potassium hydroxide / methanol / 3 h / boiling

4.2: pH 3

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 3 h / 60 - 100 °C

6.1: potassium hydroxide / methanol / 3 h / Boiling

6.2: pH 3

7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 7 h / 80 °C / Inert atmosphere

With sodium methylate; potassium carbonate; 16-Crown-5; 1,1'-carbonyldiimidazole; potassium hydroxide; In methanol; N,N-dimethyl-formamide; toluene;