3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone

Base Information

• Chemical Name: 3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone
• CAS No.: 1044749-56-5
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.798
• Mol file: 1044749-56-5.mol

Synonyms:3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone

Chemical Property of 3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone

There total 1 articles about 3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-hydroxybenzene (1789-09-9) + 1.3-chlorobromopropane (109-70-6) → 3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone (1044749-56-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1021/jm8003834

Reference yield: 80.0%

(S)-2-methylpyrrolidine hydrobromide (834878-12-5) + 3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone (1044749-56-5) → 2-methyl-3-(4-{[3-[(2S)-2-methyl-1-pyrrolidinyl]propyl]oxy}phenyl)-2-methyl-4(3H)-quinazolinone

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/jm8003834

Reference yield: 66.0%

3-{4-[(3-chloropropyl)oxy]phenyl}-2-methyl-4-(3H)-quinazolinone (1044749-56-5) + (2R,5R)-2,5-dimethyltetrahydro-1H-1-pyrrolylidium chloride (70144-18-2) → 3-[4-({3-[(2R,5R)-2,5-dimethyl-1-pyrrolidinyl]propyl}oxy)phenyl]-2-methyl-4(3H)-quinazolinone

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/jm8003834

upstream raw materials:

1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-hydroxybenzene

1.3-chlorobromopropane

Downstream raw materials:

3-(4-{[3-(3,5-dimethyl-1-piperidinyl)propyl]oxy}phenyl)-2-methyl-4(3H)-quinazolinone